Clinical Studies

No. Diagnosis Title Author(s) Year Medication(s) Design Major Outcome(s)
81 Sleep disorder Impact of Dronabinol on Quantitative Electroencephalogram (qEEG) Measures of Sleep in Obstructive Sleep Apnea Syndrome. Carley DW,
Farabi SS,
Prasad B,
Quinn L
2014 Delta-9-THC Open Study THC treatment yielded a shift in EEG (electroencephalogram) power toward delta and theta frequencies and a strengthening of normal rhythms in the sleep.
82 Multiple sclerosis Nabiximols (THC/CBD oromucosal spray, Sativex┬«) in clinical practice–results of a multicenter, non-interventional study (MOVE 2) in patients with multiple sclerosis spasticity. Flachenecker P,
Henze T,
Zettl UK
2014 Cannabis Open Study The cannabis extract Sativex provided relief in 74.6% of participants.
83 Posttraumatic stress disorder Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder. Cooper-Kazaz R,
Mechoulam R,
Roitman P,
Shalev A
2014 Delta-9-THC Open Study THC caused significant improvements in post-traumatic stress disorder (PTSD).
84 Pain,
Posttraumatic stress disorder,
Sleep disorder
Use of a Synthetic Cannabinoid in a Correctional Population for Posttraumatic Stress Disorder-Related Insomnia and Nightmares, Chronic Pain, Harm Reduction, and Other Indications: A Retrospective Evaluation. Cameron C,
Robinson J,
Watson D
2014 Nabilone Open Study Nabilone caused significant improvements in insomnia, nightmares, chronic pain and other symptoms in patients suffering from posttraumatic stress disorder (PTSD).
85 - “Safety and pharmacokinetics of oral delta-9-tetrahydrocannabinol in healthy older subjects: A randomized controlled trial.” Ahmed AI,
Burger DM,
Colbers A,
Feuth TB,
Kramers C,
Rikkert MG,
van den Elsen GA,
van der Marck MA
2014 Delta-9-THC Controlled Study THC appeared to be safe and well tolerated by healthy older individuals.
86 - Endocannabinoids control platelet activation and limit aggregate formation under flow. De Angelis V,
de Groot PG,
Herczenik E,
Koekman AC,
Roest M,
Weeterings C
2014 Other cannabinoids Open Study Activation of cannabinoid receptors by cannabis use reduces platelet activation and blood clotting.
87 Parkinson's Disease Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial Bergamaschi MM,
Chagas MH,
Crippa JA,
dos Santos AC,
Hallak JE,
Pena-Pereira MA,
Sobreira ET,
Teixeira AL,
Tumas V,
Zuardi AW
2014 Cannabidiol Controlled Study Significant improvement in well-being. No effects on motor functioning or neuroprotection.
88 Pain A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment Ehler E,
Horvorka J,
Lauder H,
Ratcliffe S,
Schofield M,
Serpell M,
Taylor L
2014 Cannabis Controlled Study Significant improvements in pain, sleep quality and subjective evaluations of patients.
89 Dependency/withdrawal Nabiximols as an agonist replacement therapy during cannabis withdrawal: a randomized clinical trial Allsop DJ,
Booth J,
Copeland J,
Dunlop AJ,
Holland RM,
Lintzeris N,
McGregor IS,
Montebello M,
Muhleisen P,
Norberg MM,
Rivas GR,
Sadler C
2014 Cannabis Controlled Study Sativex had no relevant long-term effect on cannabis dependence
90 Pain The Pharmacokinetics, Efficacy, Safety, and Ease of Use of a Novel Portable Metered-Dose Cannabis Inhaler in Patients With Chronic Neuropathic Pain: A Phase 1a Study Almog S,
Eisenberg E,
Ogintz M
2014 Cannabis Open Study A significant reduction in pain intensity was achieved after cannabis inhalation with a vaporizer.

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