Clinical Studies

No. Diagnosis Title Author(s) Year Medication(s) Design Major Outcome(s)
71 Sleep disorder Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers. Bonnet D,
Goodwin RS,
Gorelick DA,
Huestis MA,
Kelly DL,
Ortemann-Renon C,
Schroeder JR,
Schwilke E,
Schwope DM
2013 Delta-9-THC Open Study Higher THC concentrations were significantly associated with less difficulty falling asleep and more daytime sleep the following day.
72 Pain Low-dose vaporized cannabis significantly improves neuropathic pain Deutsch R,
Donaghe H,
Gouaux B,
Marcotte T,
Sakai S,
Wilsey B
2013 Cannabis Controlled Study Cannabis reduced pain. No difference in efficacy between the two doses.
73 Multiple sclerosis,
Pain
A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis. Langford RM,
Mares J,
Notcutt W,
Novakova I,
Novotna A,
Ratcliffe S,
Vachova M
2013 Cannabis Controlled Study No significant difference between placebo and Sativex in Phase A; Phase B demonstrated an analgesic effect.
74 Pain The Subjective Psychoactive Effects of Oral Dronabinol Studied in a Randomized, Controlled Crossover Clinical Trial For Pain. Edwards RR,
Issa MA,
Jamison RN,
Michna E,
Narang S,
Penetar DM,
Wasan AD
2013 Cannabis,
Delta-9-THC
Controlled Study In pain patients, oral dronabinol has similar psychoactive effects to smoking cannabis.
75 Dependency/withdrawal Cannabis as a substitute for alcohol and other drugs: A dispensary-based survey of substitution effect in Canadian medical cannabis patients. Coward M,
Earleywine M,
Lucas P,
McGowan S,
Oleson M,
Reiman A,
Thomas B
2013 Cannabis,
Delta-9-THC
Survey Many patients substitute cannabis for alcohol, illegal and medicinal drugs
76 Anxiety,
Posttraumatic stress disorder
Cannabidiol enhances consolidation of explicit fear extinction in humans. Curran HV,
Das RK,
Gupta V,
Kamboj SK,
Morgan CJ,
Ramadas M,
Redman E,
Yogan K
2013 Cannabidiol,
Delta-9-THC
Controlled Study Cannabidiol enhances consolidation of fear extinction in humans.
77 Dependency/withdrawal Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment. Scavone JL,
Sterling RC,
Van Bockstaele EJ,
Weinstein SP
2013 Cannabis,
Delta-9-THC
Open Study Objective ratings of opiate withdrawal decreased in patients using cannabis during stabilization
78 Pain The subjective psychoactive effects of oral dronabinol studied in a randomized, controlled crossover clinical trial for pain. Edwards RR,
Issa MA,
Jamison RN,
Michna E,
Narang S,
Penetar DM,
Wasan AD
2014 Cannabis,
Delta-9-THC
Controlled Study Oral THC had similar psychoactive effects to smoked marijuana
79 Epilepsy Cannabis and other illicit drug use in epilepsy patients. Ghaeni L,
Hamerle M,
Holtkamp M,
Kowski A,
Weissinger F
2014 Cannabis,
Delta-9-THC
Survey The use of cannabis did not affect disease severity in epilepsy.
80 Multiple sclerosis,
Spasticity
Clinical experiences with cannabinoids in spasticity management in multiple sclerosis. Boscá Blasco I,
Casanova-Estruch B,
Escutia Roig M,
Gil Gómez I,
Lorente Fernández L,
Monte Boquet E,
Pérez-Miralles F,
Poveda Andrés JL
2014 Cannabis,
Delta-9-THC
Open Study The cannabis extract was effective in 80% of patients.

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