Clinical Studies

No. Diagnosis Title Author(s) Year Medication(s) Design Major Outcome(s)
61 Pain Herbal cannabis use in patients labeled as fibromyalgia is associated with negative psychosocial parameters. Fitzcharles MA,
Gamsa A,
Shir Y,
Ste-Marie PA,
Ware MA
2012 Cannabis Survey Many patients with fibromyalgia use cannabis products.
62 Posttraumatic stress disorder Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence. Brandt SD,
Emrich HM,
Halpern JH,
Karst M,
Passie T
2012 Cannabis Uncontrolled case report Significant improvement in one patient with PSD with cannabis
63 - Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers. Allen P,
Atakan Z,
Batalla A,
Bhattacharyya S,
Borgwardt S,
Crippa JA,
Farré M,
Langohr K,
Martín-Santos R,
McGuire P,
Seal M,
Zuardi AW
2012 Cannabidiol,
Delta-9-THC
Controlled Study CBD does not cause significant side effects
64 Psychosis/schizophrenia Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia Gerth CW,
Hellmich M,
Hoyer C,
Klosterkötter J,
Koethe D,
Leweke FM,
Muhl D,
Pahlisch F,
Piomelli D
2012 Cannabidiol,
Delta-9-THC
Controlled Study CBD was as effective as amisulpride, a standard antipsychotic
65 Headache/migraine Use of cannabis among 139 cluster headache sufferers. Chagnon M,
Donnet A,
Ducros A,
Leroux E,
Taifas I,
Valade D
2013 Cannabis,
Delta-9-THC
Survey Less than one third of self-reported users mention a relief of their attacks following inhalation.
66 Multiple sclerosis,
Spasticity
Endocannabinoid system modulator use in everyday clinical practice in the UK and Spain. García-Merino A 2013 Cannabis,
Delta-9-THC
Open Study Sativex appears to be a well-tolerated and useful add-on therapy in patients with spasticity due to multiple sclerosis.
67 Dependency/withdrawal Nabilone decreases marijuana withdrawal and a laboratory measure of marijuana relapse. Bedi G,
Comer SD,
Cooper ZD,
Foltin RW,
Haney M,
Vosburg SK
2013 Nabilone,
Delta-9-THC
Open Study The use of nabilone reduced withdrawal symptoms.
68 Multiple sclerosis Treatment failure of intrathecal baclofen and supra-additive effect of nabiximols in multiple sclerosis-related spasticity: a case report. Chan A,
Stroet A,
Trampe N
2013 Cannabis,
Delta-9-THC
Uncontrolled case report A combination of baclofen injections into the cerebrospinal fluid and very low doses of the cannabis extract Sativex was highly effective.
69 HIV/AIDS Marijuana smoking does not accelerate progression of liver disease in HIV-hepatitis C coinfection: a longitudinal cohort analysis. Brunet L,
Cooper C,
Klein MB; Canadian Co-infection Cohort Investigators,
Moodie EE,
Potter M,
Rollet K,
Walmsley S
2013 Cannabis,
Delta-9-THC
Open Study The use of cannabis did not accelerate progression to significant liver fibrosis.
70 Cancer The medical necessity for medicinal cannabis: prospective, observational study evaluating the treatment in cancer patients on supportive or palliative care. Bar-Sela G,
Drawsheh S,
Goldberg V,
Muller E,
Omer A,
Vorobeichik M
2013 Cannabis,
Delta-9-THC
Open Study In an open clinical study with cancer patients all symptoms improved significantly.

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