Clinical Studies

No. Diagnosis Title Author(s) Year Medication(s) Design Major Outcome(s)
51 Alzheimer's disease Dronabinol for the treatment of agitation and aggressive behavior in acutely hospitalized severely demented patients with noncognitive behavioral symptoms. "Woodward MR,
Ellison JM.",
Forester BP,
Harper DG,
Stolyar A
2014 Delta-9-THC Open Study A treatment with oral THC was associated with significant decreases in agitation, as well as improvements in sleep duration and appetite.
52 Multiple sclerosis,
Spasticity
Clinical experience with THC: CBD oromucosal spray in patients with multiple sclerosis-related spasticity. Feneberg W,
Koehler J,
Meier M,
Pöllmann W.
2014 Cannabis Open Study The mean spasticity decreased by 57%.
53 Posttraumatic stress disorder Using cannabis to help you sleep: heightened frequency of medical cannabis use among those with PTSD. Babson KA,
Bonn-Miller MO,
Vandrey R.
2014 Cannabis Survey Patients with high PTSD scores were more likely to use cannabis to improve sleep, and for coping reasons more generally.
54 Parkinson's Disease Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational study. Djaldetti R.,
Lotan I,
Roditi Y,
Treves TA
2014 Cannabis Open Study Analysis of specific motor symptoms revealed significant, also sleep and pain improvement after treatment with cannabis.
55 Multiple sclerosis Long-term effectiveness and safety of nabiximols (tetrahydrocannabinol/cannabidiol oromucosal spray) in clinical practice. Flachenecker P,
Henze T,
Zettl UK
2014 Cannabis Open Study Researchers found that “real-life data confirm the long-term effectiveness and tolerability of nabiximols [Sativex] for the treatment of resistant MSS [multiple sclerosis spasticity].
56 Nausea/vomiting Cannabis for intractable nausea after bilateral cerebellar stroke. Adhiyaman V,
Arshad S.
2014 Cannabis Uncontrolled case report A woman with intractable nausea after cerebellar stroke responded well to a treatment with THC.
57 Traumatic brain injury Effect of marijuana use on outcomes in traumatic brain injury. Bongard F,
Bricker S,
Kim D,
Neville A,
Nguyen BM,
Plurad D.,
Putnam B,
Smith J
2014 Cannabis Open Study A positive THC screen is associated with decreased mortality in adult patients sustaining TBI [traumatic brain injury].
58 Multiple sclerosis,
Pain,
Spasticity
Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial. Barnes D,
Hobart JC,
Mattison PG; on behalf of the MUSEC Research Group,
Slade A,
Zajicek JP
2012 Cannabis Controlled Study Significant improvement by the cannabis extract Cannador of spasticity and pain.
59 Anxiety,
Posttraumatic stress disorder
Cannabinoid facilitation of fear extinction memory recall in humans. Abelson JL,
Angstadt M,
Liberzon I,
Milad MR,
Phan KL,
Rabinak CA,
Sripada CS
2012 Delta-9-THC Controlled Study THC prevented the recovery of fear in this experiment of extinction learning.
60 Cancer,
Pain
Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial. Allende S,
Fallon MT,
Ganae-Motan ED,
McQuade R,
Portenoy RK,
Shaiova L,
Weinstein S,
Wright S,
Yanagihara R
2012 Cannabis Controlled Study Additional pain reduction following the two lower doses.

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