Clinical Studies

No. Diagnosis Title Author(s) Year Medication(s) Design Major Outcome(s)
31 Dependency/withdrawal The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users. Huestis MA,
Lee D.,
Mintzer MZ,
Murray JA,
Stitzer ML,
Vandrey R.
2013 Delta-9-THC Open Study THC dose-dependently attenuated cannabis withdrawal.
32 - Separate and combined effects of the cannabinoid agonists nabilone and Δ(9)-THC in humans discriminating Δ(9)-THC. Hays LR,
Kelly TH,
Lile JA
2011 Delta-9-THC,
Nabilone
Controlled Study THC caused similar effects as nabilone
33 Spasticity Proof of concept trial of dronabinol in obstructive sleep apnea. Carley DW,
Prasad B,
Radulovacki MG
2013 Delta-9-THC,
Nabilone
Open Study THC significantly improved this condition.
34 - Subjective and Physiological Effects After Controlled Sativex and Oral THC Administration. Darwin WD,
Goodwin RS,
Huestis MA,
Karschner EL,
Liu F,
McMahon RP,
Wright S
2011 Cannabidiol,
Cannabis,
Delta-9-THC
Controlled Study Oral THC and the cannabis extract Sativex produced similar effects
35 Multiple sclerosis,
Spasticity
A new multiple sclerosis spasticity treatment option: effect in everyday clinical practice and cost-effectiveness in Germany. Flachenecker P 2013 Cannabis,
Cannabis,
Delta-9-THC
Open Study The cannabis extract sativex is effective in a large number of patients and well-tolerated in the long-term.
36 Appetite loss/weight loss,
Cancer,
Nausea/vomiting,
Pain,
Spasticity
[Cannabinoids in children] [Article in German] Cannabinoide bei Kindern. Gottschling S. 2011 Delta-9-THC,
Cannabis,
Delta-9-THC
Uncontrolled case report Reduced pain, spasticity and improved appetite and nausea
37 Pain Comparison of the analgesic effects of dronabinol and smoked marijuana in daily marijuana smokers. Comer SD,
Cooper ZD,
Haney M
2013 Cannabis,
Delta-9-THC,
Delta-9-THC
Controlled Study THC (dronabinol) and smoked cannabis (marijuana) caused similar effects on pain sensitivity and pain tolerance.
38 Obsessive compulsive disorder Dronabinol, a cannabinoid agonist, reduces hair pulling in trichotillomania: a pilot study. Chamberlain SR,
Grant JE,
Kim SW,
Odlaug BL
2011 Delta-9-THC,
Delta-9-THC,
Delta-9-THC
Open Study Statistically significant reduction in symptom severity.
39 Dependency/withdrawal Impact of cannabis use during stabilization on methadone maintenance treatment. Scavone JL,
Sterling RC,
Van Bockstaele EJ,
Weinstein SP
2013 Cannabis,
Delta-9-THC,
Delta-9-THC
Open Study Symptoms of opiate withdrawal decrease in patients undergoing methadone maintenance treatment, who use cannabis.
40 Epilepsy Seizure exacerbation in two patients with focal epilepsy following marijuana cessation. Garcia PA,
Hegde M,
Hess CP,
Kabir AA,
Santos-Sanchez C
2012 Cannabis,
Delta-9-THC,
Delta-9-THC
Uncontrolled case report Patients with epilepsy were able to control their seizures by the use of cannabis.

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